Freitag, 20. Juni 2014

Miscellaneous Lifespan Studies: Atenolol, Nutraceuticals, n3 fatty acids, SIRT, macronutrients and CR

Recently, I noticed that many study author have the bad habit of not providing full lifespan data, i.e. Kaplan–Meier curve as well as numerical mean and maximum lifespan (90th percentile survival) as well as numerical changes and statistical interpetation. That's just sloppy in my mind.
Another note: I think it's time to stop working with the venerable C57BL/6 ("black 6") strain in favour of more heterogenous and vigorous crosses, e.g. C57BL/6 x DBA/2n (5) or C57BL/6 x C3H (1).

Donnerstag, 5. Juni 2014

Noted for May (2014)

Brief summaries of current topics pertinent to health and life-extension. I am trying to cover "hot" topics, those with high impact and a random assortment of topics I find interesting.

1. In Pakistan, Nigeria and Afghanistan endemic Polio rears its ugly head again.

2. Flie researchers also have problems with artificial lifespan extension due to bad husbandry (ref. 2, chapter 5)

3. "Mice fear [the smell of] men", which could introduce artifacts in many life-span, or at least, health-span experiments. I guess. This could be particularly important in behavioral assays.
Exposure to the smell of males apparently leads to anxiety and analgesia.

4. Stem cell exhaustion (exhaustion of proliferative potential, atrophy) is one possible contributor to aging:
"Once the stem cells reach a state of exhaustion that imposes a limit ontheir own lifespan, they themselves gradually die out and steadily diminishthe body's capacity to keep regenerating vital tissues and cells, such asblood."

5. Juicing alters the glycemic profile of fruits/vegetables, but freezing is generally fine. Except with cruciferous vegetables, which, preferably, should not be frozen. (ref. 5, first 3 posts)

6. Cochrane found that Tamiflu may be almost completely ineffective and Roche made a large effort to hide the data.

7. Physical activity, i.e. wheel running, protects black 6 mice from osteoarthritis(OA) if it is initiated before the development of OA. Generally, black 6 develop OA early by 9 months of age and thus are not the best model for this disease.

References
1. http://www.aerzteblatt.de/nachrichten/58541/Polio-Notstand-WHO-fordert-Impfung-von-Erwachsenen (German link)

2. Sell, C., Lorenzini A. and Brown-Borg, H.M (eds): Life-span extension: single-cell organisms to man. Suresh, Rattan. Follow Journal Biogerontology , Volume 11. 2009.

3. Nat Methods. 2014 Apr 28. doi: 10.1038/nmeth.2935. [Epub ahead of print]
Olfactory exposure to males, including men, causes stress and related analgesia in rodents.
Sorge et al.

4. http://arc.crsociety.org/read.php?2,220387

5. http://arc.crsociety.org/read.php?2,220129,220134#msg-220134

6. http://pipeline.corante.com/archives/2014/05/16/the_real_numbers_on_tamiflu.php

7. Int J Rheum Dis. 2014 Mar 18. doi: 10.1111/1756-185X.12291. [Epub ahead of print]
Lifelong physical activity and knee osteoarthritis development in mice.
Hubbard-Turner T1, Guderian S, Turner MJ.